Sex-Specific Behavioral Features of Juvenile and Adult Haploinsufficient Scn2a<sup>+/-</sup> Female Mice, Model of Autism Spectrum Disorder.

We initially compared the two genotypes including all the trials, and we observed a strong trend towards increased latency in juvenile Scn2a +/− female mice (two‐way repeated measure ANOVA on both days, F (4.177, 154.5) = 8.796, p < 0.0001 for trial effect, F (1.37) = 3.895, p = 0.056 for genotype effect and F (5.185) = 0.4196, p = 0.83 for genotype × trial interaction), but no difference in adult mice (two‐way repeated measure ANOVA on both days, F (3.460, 86.51) = 4.052, p = 0.0068 for trial effect, F (1.25) = 0.9008, p = 0.35 for genotype effect and F (5.125) = 0.51, p = 0.7693 for genotype trial interaction).

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The multiple comparison of the time spent in close interaction during the social novelty phase showed a significant preference for the new unfamiliar mouse compared to the familiar one in HTZ adult females, whereas WT females showed a trend toward preference for the new unfamiliar mouse (100.1 ± 10.0 s HTZ with unfamiliar; 60.1 ± 6.6 s HTZ with familiar; 62.3 ± 5.2 s WT with unfamiliar; 41.5 ± 3.5 s WT with familiar; two‐way ANOVA, F (1.44) = 20.19, p < 0.0001 for cylinder effect, F (1.44) = 17.47, p = 0.0001 for genotype effect and F (1.44) = 2.016, p = 0.1627 for genotype × cylinder interaction; Sidak's post hoc test: WT familiar vs. unfamiliar p = 0.19, HTZ familiar vs. unfamiliar p = 0.0008, WT unfamiliar vs.

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We considered borderline significance (strong trend) when p values were between 0.05 and 0.09.

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