Barely Significant
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The LPAR1 antagonist, PIPE-791 produces antifibrotic effects in models of lung fibrosis.

Respir Res · 2025 · PMC12400753 · PMID 40887574

Europe PMCDOI
2
hedged sentences
0.0770
closest p · 1.5× alpha
0.0770
boldest claim

The sentences

did not reach statistical significancep = 0.077so close (0.05 < p ≤ 0.1)
While mice treated with 0.03 mg/kg PIPE-791 showed a trending decrease in collagen, the values did not reach statistical significance ( p = 0.077, Fig. 7 F).

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failed to reach statistical significanceno p-value reported
In both cases we observed some downregulation of fibrotic markers, but some markers failed to reach statistical significance, suggesting LPAR1 as a mechanism may be superior.

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