Collagen VII Is Associated with Airway Remodeling, Honeycombing, and Fibroblast Foci in Usual Interstitial Pneumonia/Idiopathic Pulmonary Fibrosis.

mRNA expression of collagen type I α 1 chain (COL1A1) showed a trend in being up-regulated following TGF-β1 treatment with mean FC = 4.8 ( P = 0.08) for control fibroblasts ( Figure 6 L) and mean FC = 6.6 ( P = 0.09) for IPF fibroblasts ( Figure 6 L) compared with corresponding untreated fibroblasts (FC = 1). α-Smooth muscle actin (encoded by gene ACTA2 ), a component of the cytoskeleton, is a marker of fibroblast activation to a contractile, ECM-producing phenotype.

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Although not statistically significant in TGF-β1–treated IPF fibroblasts, there was a clear trend toward COL7A1 mRNA up-regulation.

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