Association of Pharmacologic Markers of Anti-Tumor Necrosis Factor-α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis.

Despite failing to demonstrate a statistically significant relationship between either ETN concentrations or anti‐TNFα activity and ETN effectiveness, a clear trend exists that supports further study of these pharmacological markers in a larger patient cohort.

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In contrast, plasma TNFα concentrations demonstrated a highly significant and consistent relationship with ETN effectiveness by either comparing groups with or without active disease or by regression analysis based on active joint counts.

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Median plasma concentrations of ETN were 21% higher in patients with inactive disease than those with active disease; however, this difference did not reach statistical significance (Figure 4A ).

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