Barely Significant
← all excerpts

Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity.

JCI Insight · 2025 · PMC12406714 · PMID 40663394

Europe PMCDOI
3
hedged sentences
0.0001
closest p · 0.0× alpha
0.2500
boldest claim

The sentences

highly significantP < 0.0001actually significant
The effects on tumor growth between the experimental groups were highly significant: shRNA ctrl versus shRNA UNG ( P < 0.0001), shRNA ctrl plus FdU treatment versus shRNA UNG ( P = 0.003), and shRNA ctrl plus FdU versus shRNA UNG plus FdU ( P = 0.003).

also in 132,142 other papers

showed a trendP = 0.18not close (p > 0.1)
FdU treatment alone showed a trend toward enrichment for subsets of macrophages that were negative in expression of CD206 (Mac_II) and CD80 + CD86 + (Mac_VI) ( P = 0.18, P = 0.046).

also in 53,322 other papers

did not reach statistical significanceP = 0.25not close (p > 0.1)
Consistent with the CyTOF findings, there were higher mean numbers of Tc lymphocytes, although these did not reach statistical significance ( P = 0.25).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.