Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.

Consistently, mtDNA:nDNA in Slc7a11 sut/sut MuSCs demonstrated a significant trend for a decrease (p = 0.052) ( Fig. 2 I), further indicating a decreased mitochondrial content in Slc7a11 sut/sut compared to WT MuSCs.

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Furthermore, Slc7a11 sut/sut MuSCs showed a trend toward increased levels of the short isoform of OPA1 (S-OPA1) ( Supplementary Figure 2G ), consistent with the established role of S-OPA1 accumulation in response to mitochondrial stress conditions [ 45 ].

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