Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.

SUVR values from the temporal meta-ROI showed a trend toward higher average bilateral tau load in participants with asymmetric tau distribution compared to those with symmetric distribution, though this difference was statistically significant only between the right tau asymmetric group and the symmetric group (t = 2.688, p = 0.023).

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Moreover, individuals who converted from A+T- to A+T+ showed an interaction effect of baseline Aβ laterality on tau laterality over time, only trending towards significance at Braak III-IV (β = 0.081, 95%CI = [0.015; 0.147], p Bonf = 0.051) and V-VI (β = 0.093, 95%CI = [0.014; 0.171], p Bonf = 0.061).

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