Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women.

PLoS Genet · 2025 · PMC12419643 · PMID 40892850

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hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp < 0.05actually significant

The PRS T2D × sex hormone interaction term was nominally significant (p < 0.05) in all 6 models, with the most significant interaction being between PRS T2D and SHBG in women (OR 0.88, 95% C.I. 0.85-0.90, p < 2 × 10 -16 ).

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did not reach statistical significanceno p-value reported

[ 32 ] found that sex stratification identified two additional loci associated with type 2 diabetes-- CCND2 in men and GIPR in women--that did not reach statistical significance when the sexes were combined.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.