The effects of empagliflozin on diuresis and natriuresis in patients with type 2 diabetes mellitus and liver cirrhosis.

First morning urine Na/K ratio, which is considered an alternative surrogate for 24-h urine Na, showed a trend towards an increase from baseline to day 15 (P=0.096).

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populations What the new findings are: In patients with T2DM and cirrhosis, empagliflozin significantly increased diuresis without causing clinically relevant electrolyte imbalances or deterioration in renal function A trend toward increased natriuresis was observed, although the difference did not reach statistical significance Glycemic control improved over the 6-month treatment period, while renal function remained stable, with only mild and non-progressive changes observed

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