Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.

Among neuronal subtypes, splicing showed a trend in opposition to the chromatin analysis.

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Furthermore, downsampling experiments ( Methods ) revealed a clear trend in which astrocytes were most affected in AD, followed by oligodendrocytes and microglia, whereas excitatory neurons showed the lowest effects (Fig. 5a ; corrected two-sided Wilcoxon rank-sum test P values of <4.4 × 10 −14 (oligodendrocytes versus excitatory neurons), <8.3 × 10 −13 (microglia versus excitatory neurons) and <4.4 × 10 −18 (astrocytes versus excitatory neurons)).

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