Early Insights from Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Patients: An Observational Study on Polygenic Risk and Liver Biomarkers.

Int J Mol Sci · 2025 · PMC12428583 · PMID 40943344

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.0810

boldest claim

The sentences

a trend toward significancep = 0.081so close (0.05 < p ≤ 0.1)

Liver stiffness (LS) showed significant associations with AST, CAP, and FIB-4 (all p < 0.005), and a trend toward significance for ALT ( p = 0.081).

also in 3,729 other papers

did not reach statistical significanceno p-value reported

Although liver stiffness, measured by transient elastography, was numerically greater in Cohort 1 (10.3 ± 11.2 kPa) than in Cohort 2 (8.3 ± 7.9 kPa), this difference did not reach statistical significance. 2.3.

also in 111,027 other papers

showed a trendno p-value reported

MBOAT7 (rs641738), evaluated under a recessive model, was linked to higher CAP values and showed a trend toward greater fibrosis, suggesting a role in lipid remodeling and steatosis-driven fibrosis progression.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.