Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis.

In the five-pair remission cohort, IgG reactivity tended to be lower in the mild group compared with the inactive group, although this difference did not reach statistical significance ( p = 0.117).

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Patients receiving antibiotics and immunomodulators showed a trend toward lower serum IgG reactivity to gut microbial extracts, whereas administration of corticosteroids and biologics had no effect.

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