Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules.

We also observed a trend toward increased CD11b expression in CDK6 KD cells that did not reach statistical significance ( Figure 2 E) suggesting that the alteration in SSC was a consequence of increased cell granularity.

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We found a consistent trend for elevated abundance of primary granule proteins in the CDK6 −/− neutrophils ( Figure 5 A), including neutrophil elastase, proteinase 3 and myeloperoxidase (MPO), although these differences failed to reach statistical significance after correction for multiple testing.

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