Effects of CRISPR-Cas9-mediated <i>FOXP3</i> knockout on CAR T cell potency.

As expected, CAR-lacking bulk TCPs showed no killing activity, while both CAR TCPs demonstrated cytotoxicity with varying patterns across ratios, donors, and rounds, although differences did not reach statistical significance.

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While FOXP3 -KO and unmodified CAR TCPs exhibited similar exhaustion profiles, FOXP3 -KO CAR TCPs showed a trend toward enhanced effector function, including increased cytokine production and prolonged cytotoxic activity.

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