Association Between Obstructive Sleep Apnea and Reflux Disease: A Systematic Review and Meta-Analysis.

Nat Sci Sleep · 2025 · PMC12433666 · PMID 40955288

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0630

boldest claim

The sentences

approached significancep = 0.056so close (0.05 < p ≤ 0.1)

Although this trend approached significance (p = 0.056), it did not reach the conventional threshold of p = 0.05, indicating that while a potential connection may exist, it is too weak to draw definitive conclusions.

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did not reach statistical significancep = 0.056so close (0.05 < p ≤ 0.1)

A modest association between obstructive sleep apnea (OSA) and the increased incidence of gastroesophageal reflux disease (RD), with a pooled relative risk of 1.23 (95% CI: 1.00, 1.52), although this did not reach statistical significance (p = 0.056).

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a marginal trendp = 0.063so close (0.05 < p ≤ 0.1)

The overall analysis, which incorporated all severity levels, suggested a marginal trend towards significance (z = 1.86, p = 0.063), with a pooled RR of 0.72 (95% CI: 0.50–1.02).

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a trend toward significanceno p-value reported

However, the overall z-value for RSI was 1.77, with a p-value of 0.077, indicating a trend toward significance but not reaching the conventional threshold for statistical significance (p < 0.05).

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a slight trend toward significanceno p-value reported

These findings underscore that, despite a slight trend toward significance, there is no strong evidence to suggest that RD significantly impacts the severity of OSA across various phases of the disorder.

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