Sex differences in behavioral measures of anxiety in a recessive gene knockout (<i>Pink1<sup>-/-</sup></i> ) rat model of Parkinson's disease.

Post hoc comparisons similarly identified significant to near significant group/genotype differences for average velocities in testing at 3, 5 and 12 months of age [t(9) = −1.50 to −3.32, p = 0.004–0.084, d = −0.48 to −1.05, Figure 2B ] and significant to near-significant group differences in distance traveled in testing at 3 and 5 months of age [t(9) = −1.56 to −2.58, p = 0.015–0.077, d = −0.49 to −0.82, Figure 2C ]. 3.4 Total time spent per maze compartments 3.4.1 Central platform From trial to trial, most rats spent about 45–55 s in the central platform of the maze.

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A repeated measures ANOVA confirmed that in addition to main effects of Testing Age [F (1.59,25.49) = 2.89, p = 0.084; η 2 = 0.15] and interactions between Sex and Testing Age that approached significance [F (1.59,25.49) = 3.09, p = 0.073; η 2 = 0.16], there were also significant main effects of Sex [F (1,16) = 10.92, p = 0.004; η 2 = 0.41] on center space entries for the WT groups.

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