Clinical impact of real-time androgen receptor alteration monitoring on metastatic castration-resistant prostate cancer treatment in real-world settings.

Int J Cancer · 2025 · PMC12439075 · PMID 40558023

Europe PMC DOI

hedged sentences

0.0619

closest p · 1.2× alpha

0.0619

boldest claim

The sentences

did not reach statistical significancep = 0.0619so close (0.05 < p ≤ 0.1)

74 months) compared to those without detected AR alterations; however, this difference did not reach statistical significance ( p = 0.0619; Figure 4B ).

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showed a trendno p-value reported

13 , 14 , 15 , 22 , 23 , 24 AR‐V7 was strongly associated with primary resistance, with no responders observed in this subgroup (0%) while AR amplification and AR hotspot mutations showed a trend toward reduced efficacy, albeit less distinctly (50% and 60%).

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