Efficacy of Subconjunctivally Applied Everolimus- and Sirolimus-Pretreated MSCs in Preventing Diabetic Retinopathy.

This indicates a potential benefit of everolimus pretreatment in preserving cone–bipolar pathway function, although the difference did not reach statistical significance in our analysis ( P = 0.057).

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Although everolimus showed a nonsignificant trend toward better flicker ERG outcomes, both pretreatment strategies similarly protected the outer retinal layers histologically, without a significant difference between them.

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The MSC-E group exhibited significantly higher amplitudes than the DM group ( P < 0.001) and showed a trend toward higher amplitudes compared to the MSC and MSC-S groups, although these differences were not statistically significant ( P = 0.066 and 0.057, respectively) ( Fig. 5 b).

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