Efficacy of high-dose tigecycline-containing regimens for the combination treatment of carbapenem-resistant Enterobacterales bacteraemia.

JAC Antimicrob Resist · 2025 · PMC12448744 · PMID 40980597

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showed a trendno p-value reported

Conclusions HD-TGC was associated with improved microbiological clearance and showed a trend towards reduced mortality in patients with CRE bacteraemia. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2025 Jun 17; Accepted 2025 Aug 26; Collection date 2025 Oct.

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did not reach statistical significanceno p-value reported

Discussion In this propensity score-matched retrospective cohort study, HD-TGC in combination with aminoglycosides or colistin for the treatment of CRE bacteraemia was associated with a trend towards reduced 30-day all-cause mortality compared with other combination regimens, although the difference did not reach statistical significance.

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