Cross-sectional analysis of expressive and receptive language skills in Smith-Lemli-Opitz syndrome (SLOS).

J Rare Dis (Berlin) · 2025 · PMC12449423 · PMID 40979443

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hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

PPVT SS showed a trend towards a significant association with plasma cholesterol level (Spearman’s rho = −0.45, p = 0.07; corrected p = 0.086) but a nonsignificant association with CSF cholesterol level (Spearman’s rho = −0.32; p = 0.21; corrected p = 0.23).

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did not reach statistical significanceno p-value reported

However, the association between Com SS and PPVT scorability did not reach statistical significance, likely due to floor effects and limited score variability among participants with the most severe impairments.

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