Adverse Events of Immune Checkpoint Inhibitors in Cancer Patients with Comorbid Diabetes: A Real-World Pharmacovigilance Analysis of the FDA Adverse Event Reporting System Database (2011-2025).

When stratified by sex, female patients demonstrated a longer TTO (median 134.9 days, IQR 21.0 - 165.5) than males (median 123.6 days, IQR 19.0 - 145.0), although the difference did not reach statistical significance ( P = 0.091) ( Table 3 , Figure 5C ).

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Second, combination ICI therapy was associated with the highest death proportion and showed a trend toward earlier onset of AEs.

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