Potential preventive effects of angiotensin-(1-7) on bone matrix quality in diabetic rats through modulation of the organic matrix.

Biomechanical findings suggest that Ang-(1-7) treatment tended to enhance bone tissue material properties, although this did not reach statistical significance.

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In addition, the ratio of I1670/I1690 reflects the enzymatic cross-links in collagen.[ 27 , 31 ] In the DM group, this ratio was significantly lower than in the control group, suggesting that there may be significant changes in triple helix structure of collagen, since enzymatic cross-links have a significant role of maintaining stability of collagen fibrils within bone matrix.[ 36 ] However, in the group treated with Ang-(1-7), this ratio was significantly higher, indicating that Ang-(1-7) prevents the impairment of enzymatic cross-links; therefore, the impairment of triple helix structure of collagen caused by DM conditions.

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The ~I 1670 /I 1640 ratio was also significantly higher in the control group than in the DM group (p<0.05) and showed a trend toward recovery in the DM-Ang-(1-7) group, approaching control levels.

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