Opioid drug seeking after early-life adversity: a role for delta opioid receptors.

Addict Neurosci · 2024 · PMC12456463 · PMID 40995017

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hedged sentences

0.0160

closest p · 0.3× alpha

0.1200

boldest claim

The sentences

near-significantP=0.016actually significant

One-way repeated measures ANOVA revealed a significant effect of treatment dose in CTL animals, with a significant reduction in demand elasticity (α) at the highest dose of agonist relative to vehicle, and a near-significant reduction with the lower dose (F (2,22) = 5.054, P=0.016; vehicle vs.

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did not reach statistical significanceP=0.12not close (p > 0.1)

We note however that the overall interaction of ELA and opioid experience did not reach statistical significance (interaction F (1,20) =2.570, P=0.12; rearing condition F (1,20) =4.656, P=0.043; opioid experience F (1,20) =0.6877, P=0.42).

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