Surgery versus neoadjuvant chemoradiotherapy followed by surgery in locally advanced gastrointestinal tract cancers.

Front Oncol · 2025 · PMC12457145 · PMID 41001008

Europe PMC DOI

hedged sentences

0.0820

closest p · 1.6× alpha

0.0820

boldest claim

The sentences

did not reach statistical significancep=0.082so close (0.05 < p ≤ 0.1)

The R0 resection rate was higher in the CRS group, although this difference did not reach statistical significance (92.8% vs . 86.0%, p=0.082).

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showed a trendno p-value reported

Although the study was not powered to detect statistically significant differences within individual cancer types, the CRS group consistently showed a trend toward improved disease-free survival across esophageal, gastric, colorectal, and anal cancers, with the strongest effect observed in rectal and esophageal cancer patients.

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