Multimodal Neuroimaging-Guided Stratification in Amyotrophic Lateral Sclerosis Reveals Three Disease Subtypes: A Multi-Cohort Analysis.

Comparing the ALS‐IPS with clinically derived stages based on the King's College system in all ALS subjects reveals a significant trend ( p = 0.001) of higher ALS‐IPS in progressive King's College stages (Figure 3B ).

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ALS motor appeared to have the worst motor performance assessment out of all three subtrajectories, as it displayed lower ALSFRS‐R scores than both other subtrajectories and showed a trend towards the highest UMN scores among the three sub‐groups.

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Similar to the CALSNIC data, a correlation of ALS‐IPS and the disease composite score is significant in all subjects, as seen in Figure 5E , and a positive trend of higher ALS‐IPS in advanced King's College stages can be observed as well (Figure 5F ).

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