Associations of depressive symptoms with fracture in midlife women: An observational study from the Study of Women's Health Across the Nation.

These data align with the findings of Williams study, which demonstrated that exposure to depression was associated with a 1.45-fold increase in odds of fracture, albeit marginally significant ( P = .05), among women aged 20 to 93 years (median age 50.4 years) participating in the Geelong Osteoporosis Study, after adjusting for age.

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Among Caucasian/White Non-Hispanic individuals, a potential association approached significance following adjustment.

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However, this correlation did not reach statistical significance in any subgroup when additional covariates were controlled for in Model 2 (Table S2, Supplemental Digital Content, https://links.lww.com/MD/Q14 ).

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