Causal associations of renal function and sudden sensorineural hearing loss: Evidence from a two-sample multivariable Mendelian randomization study with case-control validation.

Additionally, our case–control study revealed a significant trend towards elevated Cys-C and reduced serum uric acid in patients with SSNHL.

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Similarly, the results of the risk estimation in MR Egger regression and weighted median methods demonstrated a similar trend, although the associations in the MR Egger regression methods did not reach statistical significance (Figs. 1 and 2 B).

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