Association between maternal perceived stress during pregnancy and offspring DNA methylation changes in HPA axis genes at birth in the ECHO Consortium.

In sex-stratified analyses, cg06613262 was also the top site in male only models where we observed a nominally significant association between DNAm and prenatal perceived stress (% difference = 0.028% per one-unit increase in prenatal perceived stress, P -value = .0029) ( Supplementary Table 6 ).

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Resulting P -values were larger in all four regions compared with that produced in original SKAT analyses, with associations between prenatal perceived stress and DNAm in FKBP5 and across all sites only approaching significance ( P -value FKBP5 = .055, P -value All sites = .076).

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