Hemochromatosis: A Risk Factor for Breast Cancer? Systematic Review and Meta-Analysis.

Eur J Breast Health · 2025 · PMC12462734 · PMID 40910550

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did not reach statistical significanceno p-value reported

Although this trend did not reach statistical significance, the observed signal justifies further investigation through large-scale studies with reduced heterogeneity to better determine this relationship and potentially warrant adjusting breast surveillance in carriers.

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showed a trendno p-value reported

Our meta-analysis showed a trend toward increased breast cancer risk in carriers of HFE variants, particularly C282Y homozygotes (odds ratio = 1.36, 95% confidence interval = 0.75–1.98).

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