Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery?

Int J Endocrinol · 2025 · PMC12463530 · PMID 41019282

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a clear trendno p-value reported

PCA of the lipidomic data revealed a clear trend of separation in lipid profiles between pre- and postintervention states.

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did not reach statistical significanceno p-value reported

Thyroid hormone dynamics also shifted: obese subjects exhibited a decrease in FT3 levels alongside an increase in FT4 following the intervention; TSH levels also showed a downward trend, although this did not reach statistical significance.

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