Prognostic Significance of <i>WWOX</i>/<i>HIF1A</i> Ratio in Cancer Subtypes: Insights into Metabolism, ECM, and EMT.

WWOX expression showed a trend toward significance (HR = 1.007, 95% CI: 0.999–1.016, p = 0.088).

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Although the WWOX / HIF1A ratio did not reach statistical significance, its large effect estimate and biological associations warrant further investigation in larger cohorts to clarify its prognostic utility. 3.2.

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Neither WWOX ( HR = 0.9987, 95% CI: 0.996–1.001, p = 0.26), HIF1A ( HR = 1.00, p = 0.83), nor other included variables were significant independent prognosticators, with the exception of CDK4 ( HR close to 1, p = 0.047) and CDKN1B ( HR = 0.9996, p = 0.014), which showed borderline significance.

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The WWOX / HIF1A ratio demonstrated a strong trend toward poor prognosis ( HR = 7.92, 95% CI: 0.37–168.6) but did not reach statistical significance ( p = 0.185), likely reflecting the modest cohort size and presence of high-variance cases.

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