Investigating <i>PRDM8</i> DNA Methylation in Peripheral Tissues in Borderline Personality Disorder: Association with Symptom Severity but Not Adverse Childhood Experiences.

Brain Sci · 2025 · PMC12467729 · PMID 41008310

Europe PMC DOI

hedged sentences

0.0587

closest p · 1.2× alpha

0.0587

boldest claim

The sentences

a statistical trendp = 0.0587so close (0.05 < p ≤ 0.1)

BPD patients showed a statistical trend of PRDM8 DNAm increase over DBT in their blood, which, however, did not survive correction for multiple testing ( n BPDpairs = 21, V = 68.00, p = 0.0587, p adj = 0.1174; median DNAm level [%] ± IQR blood: BPD-T1: 5.29 ± 1.37, BPD-T2: 5.62 ± 2.43).

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a strong trendno p-value reported

A within-subject analysis revealed a strong trend toward increased PRDM8 DNAm levels following treatment, driven by a significant difference at CpG site 1, although this increase in DNAm post-treatment did not remain significant after correction for multiple testing.

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nominally significantno p-value reported

Following DBT, a nominally significant increase in DNAm was observed, aligning with inversely correlated symptom severity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Investigating &lt;i&gt;PRDM8&lt;/i&gt; DNA Methylation in Peripheral Tissues in Borderline Personality Disorder: Association with Symptom Severity but Not Adverse Childhood Experiences.

The sentences

Investigating <i>PRDM8</i> DNA Methylation in Peripheral Tissues in Borderline Personality Disorder: Association with Symptom Severity but Not Adverse Childhood Experiences.