Comparative Preclinical Analysis of Anti-B7-H3 CAR-T Cells Targeting Neuroblastoma.

Biomedicines · 2025 · PMC12467967 · PMID 41007693

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did not reach statistical significanceno p-value reported

However, this increase in activity did not reach statistical significance when compared to the TE9-28z construct across the panel of tested targets.

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showed a trendno p-value reported

Of the two 8H9-based receptors, the third-generation construct (8H9-28BBz) showed a trend toward increased activation, suggesting that the presence of the CD28-signaling domain may enhance early T cell stimulation.

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