Low Vitamin D and High Psychological Distress: Are They Associated with Poor Differentiation in Head and Neck Cancer?

In summary, neither vitamin-D deficiency nor clinically significant distress independently predicted poorly differentiated tumors after adjustment, although their co-occurrence showed a trend toward higher odds (exploratory interaction p = 0.075).

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The p -value did not reach statistical significance, although a weak trend can be observed.

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Conclusions : Univariate analyses indicated potential links between vitamin D deficiency, psychological distress, and tumor aggressiveness in HNSCC, but these did not reach statistical significance after adjustment for confounders.

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The statistical significance of these associations must be interpreted with caution, as neither of the two p -values did not reach statistical significance, but rather show a marginally significant trend.

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