H&E staining of tumor sections and computational image analyses of tiles containing muscle, adipose cells, and blood vessels surrounded by cancer cells showed a clear trend of increased cancer cell invasion into the mesenchyme and muscle tissue in TSK mice, although it did not achieve statistical significance ( Figure 3 e,f).
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Notably, Pf4 and Retnla were also upregulated in melanoma and breast cancer macrophages in TSK mice compared to tumor macrophages in WT littermates, although the overexpression did not reach statistical significance ( Figure S10 ). 4.