Cytokine Profiling of Children, Adolescents, and Young Adults Newly Diagnosed with Sarcomas Demonstrates the Role of IL-1β in Osteosarcoma Metastasis.

Cancers (Basel) · 2025 · PMC12468999 · PMID 41008853

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hedged sentences

0.5200

closest p · 10.4× alpha

0.7900

boldest claim

The sentences

approached significancep = 0.52not close (p > 0.1)

Similarly, having fewer depressed cytokines correlated with slightly improved EFS, which approached significance for osteosarcoma ( Figure 3 C: Ewing sarcoma p = 0.52; osteosarcoma p = 0.082).

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did not reach statistical significancep = 0.79not close (p > 0.1)

These patients also had worse OS in osteosarcoma, but not Ewing sarcoma ( Figure 2 C: osteosarcoma p = 0.043; Ewing sarcoma p = 0.65); however, the impact on EFS did not reach statistical significance for either tumor type (Ewing sarcoma p = 0.79; osteosarcoma p = 0.55).

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