IDH Mutations and Intraoperative 5-ALA Fluorescence in Gliomas: A Systematic Literature Review with Novel Exploratory Hypotheses on the Modulatory Effect of Vorasidenib.

Cancers (Basel) · 2025 · PMC12469012 · PMID 41008917

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showed a trendno p-value reported

Among lower-grade gliomas (WHO grades 2–3), IDH-mutant tumors showed a trend toward decreased fluorescence (48.6% vs. 80.0%), although this did not reach statistical significance ( p = 0.08).

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did not reach statistical significanceno p-value reported

In glioblastoma, median OS was reported as 20.0 months for patients operated with 5-ALA, 12.3 months for those with fluorescein sodium, and 18.1 months for the combined fluorophores, with an overall median survival of 14.9 months; these differences did not reach statistical significance [ 20 ].

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