Association of Obesity-Related Genetic Variants with Android Fat Patterning and Cardiometabolic Risk in Women.

Genes (Basel) · 2025 · PMC12469512 · PMID 41009965

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0860

boldest claim

The sentences

almost reached statistical significancep = 0.052so close (0.05 < p ≤ 0.1)

The association of low HDL cholesterol values and SLC30A8 rs1326634 (dominant model) almost reached statistical significance ( p = 0.052) in WHR > 0.85 compared to ≤0.85. 4.

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marginal significancep = 0.063so close (0.05 < p ≤ 0.1)

There was also an association in the homozygous CC women’s group, but with marginal significance ( p = 0.063).

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did not reach statistical significancep = 0.086so close (0.05 < p ≤ 0.1)

HDL Cholesterol The wild genotype (TT) and homozygous (CC) genotypes in android obese women were associated with lower median levels of HDL cholesterol compared with the group with a waist-to-hip ratio (WHR) ≤ 0.85, but it did not reach statistical significance ( p = 0.086 and p = 0.071, respectively).

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a strong trendno p-value reported

In this subgroup, carriers of the allele, particularly under the dominant genetic model, exhibited higher fasting glucose and triglyceride levels, with a strong trend towards lower HDL cholesterol.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.