Polygenic Risk Score Associated with Gestational Diabetes Mellitus in an AmericanIndian Population.

J Pers Med · 2025 · PMC12470582 · PMID 41003098

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp = 6 × 10 −11actually significant

Nonetheless, the PRS indicated a highly significant association with GDM (odds ratio 1.10, 95% CI 1.07–1.13, p = 6 × 10 −11 ).

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showed a trendp = 0.070so close (0.05 < p ≤ 0.1)

The posited PRS-7 showed a trend (OR 1.56, 95% CI 0.92–2.56, p = 0.070), and sensitivity analysis comprising three variants (PRS-3) was significantly associated with GDM (OR 2.43, 95% CI 1.17–5.06, p = 0.017).

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a trend toward significanceno p-value reported

In spite of this, PRS-7 showed a trend toward significance and the PRS-3 sensitivity analysis was significant in both univariate and multivariate analyses.

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nominally significantno p-value reported

This study was of similar design, but with a much larger cohort (N = 1996); among 34 variants comprising the PRS, the odds ratio point estimate was positive in only 24, and only 8 showed a nominally significant association with GDM.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.