Metabolomics in Multiple Sclerosis: Advances, Challenges, and Clinical Perspectives-A Systematic Review.

Both nominally significant alterations ( p < 0.05) and those surviving multiple testing correction (FDR < 0.05) were reported; however, only FDR-significant findings were interpreted as robust.

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Another study reported a similar pattern of reduced KYNA and elevated 3HAA, although findings did not reach statistical significance after correction for multiple comparisons [ 42 ].

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