Fecal Short-Chain Fatty Acids to Predict Prediabetes and Type 2 Diabetes Risk: An Exploratory Cross-Sectional Study.

Nutrients · 2025 · PMC12472725 · PMID 41010528

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hedged sentences

0.0270

closest p · 0.5× alpha

0.0910

boldest claim

The sentences

a decreasing trendp = 0.027actually significant

In contrast, Alphaproteobacteria unclassified was significantly enriched in preDM compared to NonDM ( p = 0.004), while Granulicatella showed a decreasing trend in preDM that reversed in T2D ( p = 0.027).

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marginally significantp = 0.05actually significant

Microbial beta diversity analysis showed a marginally significant difference in overall community composition across groups (R 2 = 0.033, p = 0.05).

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close to significancep = 0.051so close (0.05 < p ≤ 0.1)

As expected, urinary glucose was higher in individuals with T2D (2.31 ± 6.21 g/L) compared to those with preDM (0.08 ± 0.05 g/L) and NonDM (0.45 ± 1.42 g/L), with a p -value close to significance ( p = 0.051).

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showed a trendp = 0.091so close (0.05 < p ≤ 0.1)

Fecal propionic and butyric acid levels showed a trend towards lower concentrations in people with T2D compared either to NonDM ( p = 0.091) and preDM ( p = 0.090), respectively; however, these differences did not reach statistical significance.

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did not reach statistical significanceno p-value reported

Fructose and sucrose levels were also higher in T2D, although differences did not reach statistical significance. 3.2.

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