Effect of controlled human Plasmodium falciparum infection on B cell subsets in individuals with different levels of malaria immunity.

There was a significant (or borderline significant) and positive effect of vaccination for rcMBCs (β = 0.190, 95% CI 0.011–0.368, p = 0.037) (Fig. 5 ) at D11, and for active naïve-PD1 + (β = 0.637, 95% CI 0.058 to 1.217, p = 0.031) (Fig. 5 ), acMBC-IgG + (β = 0.166, 95%CI − 0.025 to 0.358, p = 0.088) and PCGCs (β = 0.874, 95%CI − 0.137 to 1.884, p = 0.090) at D84.

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At D11, aaMBC frequency had a borderline non-significant positive association with infection (Supplementary Table 3 and Fig. 7 ).

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In those individuals, the frequency of aaMBCs correlated negatively with eotaxin levels, but this result did not reach statistical significance (Figure S5).

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