IGRA-positive national screen program examinees showed a trend of increased risk of TB incidence with increasing interferon level; this trend was prominent in younger individuals, but not in older adults aged ≥65 years.
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[Tuberculosis Risk and Efficacy of Latent Tuberculosis Infection Treatment among Participants of National Latent Tuberculosis Infection Screening Program].
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Such a trend was much less prominent in the 35–49 and 50–64 age groups, while a significant trend was not observed in the ≥65 age group.