Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation.

Notably, LTP in PV + interneurons was markedly suppressed in the KI mice, although there was a clear trend towards enhancement—albeit not statistically significant—upon treatment with a higher concentration of 60 μM DCS (Fig. 5F ).

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Notably, treatment with 60 μM D-cycloserine exhibited a marked trend toward restoring LTP in these interneurons, although statistical significance was not yet achieved—possibly due to the need for higher concentrations or prolonged pre-incubation.

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