Fiducial tracking fidelity in robotic prostate SBRT: a comparison of a 3-fraction boost following pelvic nodal irradiation and definitive 5-fraction treatment.

Radiat Oncol · 2025 · PMC12487326 · PMID 41029748

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

approached significancep < 0.058so close (0.05 < p ≤ 0.1)

However, use of concomitant ADT approached significance when analyzing median volatility in the 5- versus the 3-fraction cohort (1.12 versus 2.24, p < 0.058).

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nearly reached significancep = 0.058so close (0.05 < p ≤ 0.1)

The one possible exception was the use of concomitant ADT, which yielded excess volatility that nearly reached significance (1.12 vs. 2.24, p = 0.058).

also in 24 other papers

near significanceno p-value reported

One limitation of the present study is a lack of power, particularly given the near significance of ADT clinical use as it relates to fiducial tracking volatility.

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nearly achieved significanceno p-value reported

The fact that the use of ADT nearly achieved significance indicates this prolonged neoadjuvant ADT approach may be prudent to mitigate fiducial tracking fidelity issues.

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