Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease.

Although no striatal gene expression changes reached significance following FDR correction (FDR <0.1) in HTT-ASO-treated YAC128 mice at the 6-month time point, we identified 105 downregulated and 148 upregulated genes that were nominally significant ( p < 0.05) in response to treatment ( Table S2 ).

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We observed a strong trend toward increased PLP1 levels ( Figure 8 H; one-way ANOVA: p = 0.051; unpaired t test: p = 0.052 HTT ASO vs.

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