FTO inhibition attenuates renal fibrosis by downregulating ferroptosis activator ACSL4 and profibrotic factor TGFBI.

58 FTO KO significantly upregulated m 6 A levels at site 1,036 determined by site-specific m 6 A qPCR ( Figure 5 H), whereas the upregulation at site 481 approached significance for each knockdown target sequence ( p = 0.07 and 0.09) ( Figure S3 C), suggesting that FTO directly regulates ACSL4 expression by demethylating its transcript.

also in 8,237 other papers

The number of mice used was determined based on a pilot study showing a near-significant difference with the same treatments using three mice per group.

also in 2,306 other papers