Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.

Across all sexes and strains, fasting insulin levels were correlated with dietary Ile levels, with the highest levels generally observed in WD High Ile fed mice and the lowest in WD Low Ile-fed mice, though these differences did not reach statistical significance in DBA females ( Fig. 2 D).

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When stratifying individuals by decile of protein energy intake (% of kcals), a clear trend emerged with lower protein consumers eating a lower relative proportion of isoleucine ( Fig. 7 C).

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