Expanded CD16⁺CD56⁺Granzyme B⁺ NK like CD8⁺ T cells an off target effect of bruton's tyrosine kinase inhibitors in Waldenström macroglobulinemia.

A significant decrease in RBD + B cells was observed when BTKi grouped patients (median = 0.12 per 10 6 lymphocytes) and treatment naïve (median = 41.8 per 10 6 lymphocytes) patients, that approached significance ( p = 0.0238) (Fig. 4 B).

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3A) and the CD4 + :CD8 + ratio population but this did not reach statistical significance (median = 2.4% vs. 0.7, p = 0.285) (Supplementary Fig. 3C).

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