Comparative Efficacy of Montelukast-Levocetirizine Combination Therapy versus Monotherapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Int Arch Allergy Immunol · 2026 · PMC12503583 · PMID 40664175

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showed a trendno p-value reported

Although combination therapy showed a trend toward greater improvement in eye symptoms compared to both monotherapies (levocetirizine: SMD [95% CI]: −0.75 [−2.11 to 0.61]; I 2 = 97.2%, montelukast: SMD [95% CI]: −1.30 [−2.85 to 0.26]; I 2 = 96.7%), these differences were not statistically significant.

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did not reach statistical significanceno p-value reported

Compared with levocetirizine monotherapy, combination therapy showed greater improvements in daytime symptom scores (SMD [95% CI]: −0.48 [−0.83 to −0.13]; I 2 = 50%), while the reduction in nighttime symptoms did not reach statistical significance (SMD [95% CI]: −0.20 [−0.45 to 0.05]; I 2 = 0%) ( Table 2 ).

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